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BBC seminar series

Thursdays, Mission Bay, Genentech Hall Auditorium 12:00-1:00 PM, simulcast to Parnassus, Medical Sciences, S-161

Academic Year 2015

Date Speaker Topic Host
9/25/14 Elaine Kirschke Clements Lecture Dave Agard
10/2/14 Phil Geissler, UC Berkeley Quantifying the diversity of side-chain fluctuations in folded proteins Kale Kundert
10/9/14 Hashim Al-Hashimi, Duke Role of Nucleic Acid Dynamics in the Central Dogma of Molecular Biology James Fraser
10/16/14 Lior Pachter, UC Berkeley TBA Daniel Himmelstein
10/23/14 Gail Fanucci, University of Florida Mechanisms of Drug Resistance in HIV-1 Protease Explored by EPR and NMR Spectroscopies John Gross
11/6/14 Laura Kiessling, University of Wisconsin Braisted Lecture: Us Versus Them: Cell Surface Glycans to Distinguish Human and Microbial Cells Jim Wells
11/13/14 Jeff Gore, MIT Cooperation, cheating, and collapse in microbial populations Matt Thomson
11/20/14 Molly Przeworski, University of Chicago An evolutionary perspective on the human germline mutation rate Tara Friedrich
1/8/15 Mark Murcko, Disruptive Biomedical Kollman Lecture John Gross
1/15/15 Edward Marcotte, University of Texas at Austin TBA James Webber
1/22/15 Barak Cohen, Washington University in St. Louis TBA Nadav Ahituv
1/29/15 Stephen Montgomery, Stanford TBA Katie Pollard
2/5/15 Robert Keenan, University of Chicago TBA Bill DeGrado
2/12/15 Judith Klinman, UC Berkeley TBA Susan Miller
2/19/15 Anne-Claude Gingras, Lunenfeld TBA Rebecca Levin
2/26/15 Samie Jaffrey, Cornell Imaging RNA and RNA biology using RNA mimics of green fluorescent protein David Weinberg
3/5/15 Ruth Nussinov, NIH Signaling pathways in cancer Diego Garrido Ruiz
3/12/15 Andrew Benson, University of Nebraska TBA Katie Pollard
4/2/15 Jennifer Doudna, UC Berkeley TBA Bill DeGrado
4/16/15 Ronald Raines, University of Wisconsin TBA Sam Pollock
4/23/15 Jeffrey Hubbell, EPFL TBA Tejal Desai
4/30/15 Vlad Denic, Harvard Activation of Atg1 kinase by receptor-bound targets initiates selective autophagy Jonathan Weissman
5/7/15 Jennifer Prescher TBA Zev Gartner
5/14/15 Evgeny Nudler, NYU TBA Leo Gendelev
5/21/15 Ming Hammond, UC Berkeley Riboswitches as privileged scaffolds for in vivo sensing, directed evolution, and targeting Danica Galonic Fujimori
5/28/15 Michael Elowitz, Cal Tech TBA Brian Sharon

Academic Year 2014

Date Speaker Topic Host
9/26/13 Laura Lavery Clements Lecture: Molecular asymmetry provides new insights into Hsp90 mechanism Dave Agard
10/17/13 Richard Bonneau, NYU Integrative computational methods for learning dynamic regulatory models: application to T-cell differentiation and function Andrew Sczesnak
10/24/13 David Bartel, MIT MicroRNAs and a developmental switch in the nature of translational control. Hiten Madhani
10/31/13 Erin Carlson, Indiana University Chemical Probes to Explore and Inhibit Bacterial Pathogenesis Danica Galonic Fujimori
11/21/13 Dana Pe'er, Columbia University What can you do with 40 dimensions in single cells, mapping development, signal processing and disease? Wendell Lim
1/9/14 Wah Chiu, Baylor College of Medicine Structures of Viruses Inside and Outside the Host Cells Yifan Cheng
1/16/14 Kevin Healy, UC Berkeley Disease-Specific Microphysiological Human Organ Models: the Future of Personalized Medicine? Bruce Conklin
1/23/14 David Mooney, Harvard Biomaterials as therapeutic cancer vaccines Tejal Desai
1/30/14 Kate Carroll Painting the Cysteine Chapel: New Tools to Probe Oxidation Biology Bill DeGrado
2/13/14 Benjamin Cravatt, Scripps Activity-based proteomics - applications for enzyme and inhibitor discovery. Christina Fitzsimmons & Becca Levin
2/20/14 Claudio Joazeiro, Scripps Listerin/Ltn1 links Co-translational Protein Quality Control and Neurodegeneration. Jonathan Weissman
2/27/14 Bianxiao Cui, Stanford Light-controlled intracellular signaling pathways in cell fate determination Bo Huang
3/13/14 Tim Hughes, University of Toronto Kaleidoscopic evolution of C2H2 zinc finger DNA binding Nevan Krogan
4/3/14 Tack Kuntz, Kollman Lecture Computation, Modeling & Evolution at UCSF: Past, Present, Future John Gross
4/10/14 David Baker, University of Washington Design of protein structures, functions and assemblies Jennifer Kung & Justin Rettenmaier
4/17/14 Rama Ranganathan, UT Southwestern The evolutionary "design" of proteins Sara Calhoun & Diego Garrido Ruiz
4/24/14 Alexander Hoffman, UCSD Network Dynamics as a basis for Specificity Hana El Samad
5/1/14 Dorothee Kern, Brandeis The evolution of kinase dynamics over 1 billion years reveals Gleevec's selectivity James Fraser
5/8/14 Trey Ideker, UCSD Siri of the Cell: What Biology Can Learn From The iPhone. James Webber
5/15/14 L. Mahadevan, Harvard A physical basis for morphogenesis? Matt Thomson
5/22/14 Cliff Brangwynne, Princeton Intracellular Phase Transitions and Cell Size Dyche Mullins
5/29/14 Johan Paulsson, Harvard Quantifying dynamics in single cells Graham Heimberg

Academic Year 2013

Date Speaker Topic Host
9/27/12 Sheng Zhong, U Illinois Comparative Epigenomics: a case study of human, mouse and pig pluripotent stem cells. Bo Huang
10/11/12 Caleb Bashor Clements Lecture Wendell Lim
10/18/12 Dianne Newman, CalTech New interpretations of ancient biomarkers: exploring the functions of (2-methyl) hopanoids, steroid analogs in bacteria Joe Kliegman
10/24/12 Stuart Schreiber, Harvard University Braisted Lecture, Cancer genetic dependencies targeted by small molecules Jim Wells
11/8/12 Doug Lauffenberger, MIT In Vivo Systems Analysis of Cell-Cell Communication and Signaling in Inflammation Kathy Giacomini
11/15/12 Robert Lamb, Northwestern Activating protein re-folding to cause paramyxovirus-mediated membrane fusion Bill DeGrado
11/28/12 Greg Verdine, Harvard Cancer Chemical Biology Jim Wells
11/29/12 Sunney Xie, Harvard Life at the Single Molecule Level David Burkhardt
1/10/13 Susan Marqusee, UC Berkeley Sequence Determinants of a Protein's Energy Landscape Henry Lin
1/17/13 David Odde, University of Minnesota Microtubule self-assembly kinetics Wallace Marshall & Dyche Mullins
1/24/13 Wenying Shou, Fred Hutchinson Cancer Center War and peace: a biological basis for population segregation and mixing Wallace Marshall
2/7/13 Jonathan Javitch, Columbia A tale of two substrates: a novel mechanism for neurotransmitter:sodium symport Robert Edwards
2/14/13 Michael Levitt, Stanford Combinatorial Methods Solve a Difficult Structural Problem to Reveal How Chaperonins Work in Eukaryotes John Gross
2/21/13 Bridget Carragher, Scripps Investigating the dynamics of molecular machines using automated electron microscopy Bob Stroud
2/28/13 David Liu, Harvard Small-molecule and macromolecule discovery driven by evolution Zev Gartner
3/7/13 Michael Laub, MIT Specificity and evolution of bacterial signaling pathways. Anthony Shiver
3/14/13 Celeste Nelson, Princeton Physical control of tissue morphogenesis Zev Gartner
4/11/13 Brenda Schulman, St. Jude Children's Research Hospital Twists and Turns in Ubiquitin Conjugation Cascades John Gross
4/18/13 Garry Nolan, Stanford A structure for cancer and immunity at the single cell level by mass cytometry Justin Rettenmaier
4/25/13 Adrian Keatinge-Clay, University of Texas Visualizing and harnessing polyketide assembly lines Bob Stroud
5/2/13 Laura Kiessling, University of Wisconsin-Madison Probing and Perturbing the Cell's Glycan Coat Kevan Shokat
5/16/13 Jeffrey Skolnick, Georgia Tech Interplay of physics and evolution in the likely origin of protein biochemical function Peter Cimermancic

Academic Year 2012

Date Speaker Topic Host
9/29/11 Vijay Pande Some surprises in the Biophysics of Protein Dynamics Emmanuel Yera, Jain Lab, Computational Student Group
10/13/11 Jure Leskovec Computational Perspectives on the Structure and Information Flows in On-Line Networks Michael Fischbach
10/13/11 Jure Leskovec, Stanford TBA Michael Fischbach
10/20/11 BP Clements Best Thesis Talk, Anselm Levskaya Closed Loop Optogenetics for the Study of Neural Circuitry In Vivo Chris Voigt
10/27/11 Jim Ferrell, Stanford Dissecting the Mitotic Trigger Wendell Lim
11/3/11 Adam Cohen, Harvard TBA Bo Huang
11/17/11 Galit Lahav, Harvard Encoding information through protein dynamics Wendell Lim, Center for Systems & Synthetic Biology
12/1/11 Doug Lauffenberger, MIT Quantitative Cell Bioengineering Analysis of EGF Receptor Inhibitor Effectiveness in Cancer Therapeutics Kathy Giacomini, QBC Sponsored
12/7/11 Tom Tuschl Characterization of regulatory small RNAs and RNA-binding proteins Michael McManus
1/12/12 Ivan Ovcharenko, NIH NCBI Computational strategies for deciphering the sequence encoding of gene regulatory elements Mee J Kim, Ahituv Lab
1/19/12 Kristala Jones Prather, MIT Parts, Devices, and Chassis in Support of Metabolic Engineering David Booth
1/26/12 Robert Austin, Princeton Darwinian Evolution: Not As Slow as You Might Think Wallace Marshall
2/16/12 Mina Bissell, LBNL Why don't we get more cancer? The proposed role of the microenvironment in tissue specificity and breast cancer Crystal Nyitray, Student
2/23/12 Amy Palmer, University of Colorado Developing fluorescent tools for live cell imaging Xiaokun Shu
3/1/12 Rami Hannoush Chemical tools to perturb and image Wnt signaling Danica Galonic Fujimori
3/15/12 Harmit Malik, Fred Hutchinson Cancer Center Genetic conflicts: the usual suspects and beyond John Gross
4/5/12 Ian Wilson, Scripps Broad neutralization of HIV and influenza viruses Bob Stroud
4/12/12 Michelle Chang, UC Berkeley Building new chemical function in living organisms Jack Taunton, Kevan Shokat
4/19/12 Alan Engleman, Farber Cancer Center Retroviral integrase function and drug resistance mechanisms Bob Stroud, HARC Sponsored
4/26/12 Howard Hang, Rockefeller Chemical Reporters for Protein S-Palmitoylation in Cell biology and Innate Immunity Danica Galonic Fujimori
5/3/12 Russ Altman, Stanford The emerging network of data for linking genes and drugs Chris Wen, Giacomini Lab, Computational Student Group
5/17/12 Jennifer Lippincott-Schwartz, NIH Mitochondria, metabolism and cell cycle control: an imaging perspective Amanda Silber and Si-Han Chen, Students
5/24/12 Ira Mellman, Genentech Next Generation Approaches to Basic Cell Biology & Drug Discovery Justin Rettenmaier, Wells Lab
5/31/12 Jim Ferrell Dissecting the Mitotic Trigger Wendell Lim
5/31/12 Jim Ferrell Dissecting the Mitotic Trigger Wendell Lim
5/31/12 Jim Ferrell, Stanford Dissecting the Mitotic Trigger Wendell Lim

Academic Year 2011

Date Speaker Topic Host
9/30/10 Ehud Isacoff, UC Berkeley TBA Pam England
10/14/10 Quincey Justman, BP Alum TBA Kevan Shokat
10/21/10 Amy Keating, MIT TBA Tanja Kortemme
10/28/10 Bill De Grado, Braisted Talk TBA
11/18/10 Bonnie Bassler, Princeton TBA Joe Kliegman
12/2/10 Lei Wang, Salk Institute TBA Jack Taunton
1/13/11 David Case, Rutgers TBA Tom James
1/20/11 Hening Lin, Cornell TBA Danica Galonic & Jack Taunton
1/27/11 Adrian Elcock, University of Iowa TBA Andrej Sali
2/3/11 Erik Winfree, Cal Tech TBA Felix Moser, Voigt Lab
2/17/11 Jonathan Eisen, UC Davis TBA Peter Skewes Cox and DeRisi Lab
2/24/11 Ning Zheng, University of Washington TBA Jack Taunton
3/3/11 Charalampos Kalodimos, Rutgers TBA Gross Lab, Robin Aglietti
3/17/11 David Price, University of Iowa TBA HARC Center, Alan Frankel
4/14/11 Mark Yeager, University of Virginia TBA HARC Center, Yifan Cheng
4/21/11 CANCELLED: Niles Pierce, Cal Tech TBA Hana El Samad
4/27/11 Chris Chen, U Penn TBA Tejal Desai and Sai Duriseti
4/28/11 Bill Noble, University of Washington TBA Genevieve Erwin, Pollard Lab
5/5/11 Eduardo Perozo, University of Chicago TBA David Julius
5/12/11 Bruce Roth, Genentech TBA Brian Shoichet
5/19/11 TBA TBA
5/26/11 Alexander Van Oudenaarden, MIT TBA
6/2/11 Linda Hsieh-Wilson, Cal Tech TBA Al Burlingame and Samuel Myers

Academic Year 2010

Date Speaker Topic Host
10/1/09 Jeremy Wilbur, Clements Recipient Clements Distinguished BP Award Talk: Mechanisms for Scaling the Mitotic Spindle
10/15/09 Alice Ting, MIT TBA Orion Weiner Lab, Sheel Dandekar
10/22/09 Bill Jorgensen, Yale TBA Matt Jacobson
10/29/09 Mark Mayer, NIH TBA Dan Minor
11/19/09 Niko Grigorieff, Brandeis TBA Yifan Cheng
12/3/09 Rachelle Gaudet, Harvard TBA Lily Jan
1/14/10 James Berger, UC Berkeley TBA Dan Minor
1/21/10 Andy McCammon, UCSD TBA Ken Dill
2/11/10 Gerald Joyce, Scripps TBA Mike Lopez and Kevan Shokat
2/24/10 Louise Jonson, Oxford TBA Bob Stroud, HARC Sponsored
2/25/10 W.E. Moerner, Stanford TBA Matt Jacobson
3/11/10 Angela Gronenborn, University of Pittsburgh TBA John Gross, HARC Sponsored
3/18/10 Susan Taylor, UCSD TBA Matt Jacobson and Jim Wells
4/1/10 Daniel Herschlag, Stanford TBA Babbitt Lab, Michael Hicks
4/15/10 Jon Ellman, UC Berkeley TBA Charly Craik
4/22/10 Edward Holmes, Penn State TBA Andino Lab, Cecily Burrill
4/29/10 Peter Sorger, Harvard TBA Philip Merksamer, Papaz Lab
5/13/10 Phil Cole, Johns Hopkins TBA Danica Galonic Fujimori
5/20/10 Danny Tawfik, Weizmann Institute of Science TBA Brian Shoichet
5/27/10 Erik Sorensen, Princeton TBA Brian Shoichet
6/3/10 Eric Gouaux, OHSU TBA Rob Edwards

Academic Year 2009

Date Speaker Topic Host
10/2/08 David Savage Clements Talk: The Carbon Cycle at a Molecular Level: Design Principles of Cyanobacterial and Yeast Metabolism
10/16/08 Jamie Williamson, Scripps Ribosome assembly: watching a machine assemble in vitro and in cells using mass spectrometry S. Floor
10/23/08 Bruce Cohen, LBNL-Biological Nanostructures Facility of the Molecular Foundry Smart Nanoparticles and the Future of Bioimaging Lily Jan
10/30/08 Ruben Gonzalez, Columbia Coupling of ribosome and tRNA dynamics during translation elongation
11/13/08 Sharad Ramanthan, Harvard "Deforming signaling networks: using evolutionary analyses to re-wire kinase pathways." H. El-Samad
11/20/08 Jean-Louis Reymond, Univ. of Berne Switzerland "Exploration of Chemical Space for Drug Discovery by Database Generation" B. Shoichet
12/11/08 A. Joshua Wand, University of Pennsylvania The dark energy of proteins: Conformational entropy and its contribution to molecular recognition by proteins C. Mcclendon
1/15/09 James Chou, Harvard The Proton Channels of Influenza Virus John Gross
1/22/09 Anand Asthagiri, Cal Tech "From molecular networks to multicellular phenotypes" Hana El-Samad
1/29/09 Tom Muir, Rockefeller Testing the ‚Histone Code‚Hypothesis Using Synthesis
1/30/09 Benoit Roux, University of Chicago QB3/iPQB Invitational Speaker Series Dill and Jacobson Labs
2/12/09 Richard Friesner, Columbia Computational Modeling of Protein-Ligand Interactions: Successes, Challenges, and Prospects. Matt Jacobson
2/19/09 Chris Miller, Brandeis Chloride transporters and chloride channels all mixed up Dan Minor
2/27/09 Sumit Chanda, Burnham Institute Global Analysis of HIV host-pathogen interactions using RNAi Frankel Lab
3/12/09 Bryan Roth, UNC, Chapel Hill Synthetic and chemical biological approaches for modulating neuronal signaling in vivo Brian Shoichet
3/13/09 Uri Alon, Weizman Institute of Science QB3/iPQB Invitational Speaker Series El Samad Lab
3/19/09 James Chen, Stanford Chemical probes of embryonic signaling and patterning
3/20/09 Jeff Kelly, Scripps Research Institute QB3/iPQB Invitational Speaker Series Shoichet Lab
4/2/09 Joachim Frank, NYU Ribosomal Dynamics during Translation Rebeca Choy
4/16/09 Wes Sundquist, University of Utah The Biochemistry of HIV Budding Alkan Frankel
4/23/09 Vern Schramm, Albert Einstein College of Medicine Enzymatic Transition States: Drugs and Dynamics. Danica Galanic Fujimori
4/24/09 Ian Haworth, USC QB3/iPQB Invitational Speaker Series Sali Lab
4/30/09 Deborah Hung, Harvard TBA
5/14/09 TBA Braisted Lecture
5/21/09 Annelise Barron, Stanford Robust, non-natural Aupeptoid, Au mimics of antimicrobial peptides for potent, selective bacterial pathogen killing Ken Dill
5/28/09 Andy McCammon, UCSD TBA
5/29/09 Aviv Regev, Broad Institute QB3/iPQB Invitational Speaker Series Weissman Lab
6/12/09 Steven Boyd, University of Calgary QB3/iPQB Invitational Speaker Series Majumdar Lab

Academic Year 2008

Date Speaker Topic Host
10/11/07 Nick Endres, UC Berkeley Clements Talk: Using artificial lipid membranes to gain insights into the structure and function of signaling proteins in the EGFR/Ras signaling network D. Agard
10/18/07 Justin Gallivan, Emory University Reprogramming Bacteria with Small Molecules and RNA P. England
10/25/07 Jack Szostak, Harvard Medical School Braisted Lecture: Towards the Design and Synthesis of an Artificial Cell C. Craik and J. Wells
11/1/07 Peter Wright, Scripps Exploring the protein energy landscape: Disorder, dynamics, and protein function S. Miller
11/15/07 Paul Hergenrother, University of Illinois Using small molecules to identify novel targets for the treatment of cancer J. Taunton
11/29/07 David Baker, U Washington Novel enzyme catalysts, rapid structure determination, and pushing the limits of folding and design with a multiplayer online computer game J. Wells
12/13/07 David Deamer, UC Santa Cruz Nanopore analysis of DNA K. Dill
12/20/07 Lewis Kay, University of Toronto Seeing the invisible by solution NMR spectroscopy T. James
1/3/08 Rob Phillips, Caltech How Cells Decide What to Eat and Where to Go W. Marshall
1/10/08 Tom Knight, MIT TBA R. Williams
1/17/08 Tom Wandless, Stanford A General Solution to the "Problem" of Chemical Genetics J. Taunton
1/24/08 Gaudenz Danuser, Scripps Integration of mechanical and chemical signals in cell migration deciphered by global fluctuation analysis W. Marshall
2/14/08 Eric Siggia, Rockefeller University Predicting the course of evolution H. Li
2/21/08 Susan Marqusee, UC Berkeley TBA K. Dill
2/28/08 James Inglese, NIH Chemical Genomics Center Integrative Technologies Enabling Chemistry and Biology as a Public Resource for Chemical Probe and Drug Discovery B. Shoichet
3/13/08 Gavin MacBeath, Harvard University TBA
3/20/08 Ned Wingreen, Princeton Modeling the chemotaxis network of E. coli C. Tang
4/17/08 Tudor Oprea, University of New Mexico From Digital to Experimental Bioactivity: Exploring novel estrogen receptors B. Shoichet
4/24/08 Richard Ebright, Rutgers Single-molecule analysis of transcription G. Narlikar
5/1/08 Vishva Dixit, Genentech, Inc. The Inflammasome & Deubiquitinases in Innate Immune Signaling J. Wells
5/15/08 Rachel Brem, UC Berkeley Expression variation and regulatory feedback K. Dill
5/22/08 Jagesh Shah, Harvard Medical School Biophysical measurements of mitotic checkpoint signaling: How cells prevent chromosome loss W. Marshall
5/27/08 Gary Ruvkun, Harvard University TBA
5/29/08 Brian Chait, Rockefeller University Protein Interactions as a Window into Cellular Function A. Krutchinsky
6/5/08 Gerald Crabtree, Stanford Designing small molecules to regulate protein interactions

Academic Year 2007

Date Speaker Topic Host
10/12/06 Mathew Francis, UC Berkeley New chemical tools for site-selective protein modification P. England
10/19/06 Adrian Keatinge-Clay, UCSF Dissecting, deciphering, and designing polyketide assembly lines R. Stroud
10/26/06 Christopher Walsh, Harvard Andrew Braisted Lecture, Halogenases: Natural product tailoring enzymes C. Craik
11/2/06 Ron Weiss, Princeton Synthetic biology: from bacteria to stem cells C. Voigt
11/16/06 Jay Keasling, UC Berkeley Engineering microorganisms for production of inexpensive, effective, anti-malarial drugs C. Craik
11/30/06 Sarah O'Connor, MIT Biosynthesis of new alkaloids in periwinkle K. Shokat
12/14/06 Maurizio Pellecchia, Burnham Institute A million little pieces: Fragment based approaches to drug discovery M. Jacobson
1/11/07 David Weitz, Harvard Reconstituted networks as models of cell mechanics W. Marshall
1/18/07 Richard H. Kramer, UC Berkeley Engineering light-activated ion channels for remote control of neuronal activity R. Edwards
1/25/07 Edward Egelman, University of Virginia Polymorphic perversity in polymers: The biological role of multiple subunit interfaces in helical filaments D. Mullins
2/1/07 Christina Smolke, Caltech Engineering molecular sensors for probing and programming cellular systems H. El-Samad
2/22/07 Alice Ting, MIT New protein labeling methodology and application to single molecule imaging of receptor trafficking with quantum dots J. Wells
3/1/07 Lorena Beese, Duke An integrated view of DNA polymerization and repair R. Stroud
3/15/07 Wilfred van der Donk, University of Illinois Chemistry and biology of ianthionine synthesis J. Taunton
4/12/07 David Tirrell, California Institute of Technology Non-canonical amino acids in protein engineering and proteomic analysis P. England
4/19/07 Brenda Bass, University of Utah dsRNA binding proteins in RNA editing and RNA interference J. Gross
4/26/07 Adrian Gross, Northwestern Structural aspects of potassium channel function B. Shoichet
5/10/07 Pei Zhou, Duke University Medical Center From novel antibiotics to fast NMR J. Gross
5/17/07 Melissa Jurica, UCSC Spliceosome structure by cryo-EM reconstruction G. Narlikar
5/24/07 Phil Baran, Scripps The catalytic cycle of discovery in total synthesis A. Renslo
5/31/07 William Bialek, Princeton Physics problems in early embryonic development R. Fletterick
6/7/07 Luc Jaeger, UC Santa Barbara Exploring folding, assembly and design principles of RNA as a proto-language A. Frankel

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