Current Events

Genevieve Erwin

Functional Characterization of the Antibiotic Resistance Reservoir in the Human Microflora, by Morten O. A. Sommer, Gautam Dantas, and George M. Church, from Science (Aug 28, 2009)

Megan Riel-Mehan

Chemical Dissection of an Essential Redox Switch in Yeast Candice E. Paulsen1 and Kate S. Carroll1,2,3,* 1Chemical Biology Graduate Program 2Department of Chemistry 3Life Sciences Institute University of Michigan, Ann Arbor, MI 48109-2216, USA *Correspondence: katesc@umich.edu DOI 10.1016/j.chembiol.2009.01.003

Charlie Morgan

"Visualization of ATP levels inside single living cells with fluorescence resonance energy transfer-based genetically encoded indicators" Imamura, H., et al. PNAS Sept 15 2009.

Geoff Rollins

Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic Smith et al. Nature 459, 1122-1125 (2009)

Joanna Lipinski

"Programming cells by multiplex genome engineering and accelerated evolution" Wang H, Isaacs F, Carr P, Sun Z, Xu G, Forest C, Church G. Nature 460, 894-898 (13 August 2009)

Edwin Rodriguez

An Unfolded CH1 Domain Controls the Assembly and Secretion of IgG Antibodies Matthias J. Feige,1 Sandra Groscurth,1 Moritz Marcinowski,1 Yuichiro Shimizu,2 Horst Kessler,1 Linda M. Hendershot,2 and Johannes Buchner1,* Molecular Cell 34, 569–579, June 12, 2009

Idelisse Ortiz Torres

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling Nature 461, 614-620 (1 October 2009) | doi:10.1038/nature08356;

Chris Fuller

"Unbiased Reconstruction of a Mammalian Transcriptional Network Mediating Pathogen Responses" by Ido Amit, et al. It's in the October 9th issue of Science.

Dan Lu

Protein sectors: evolutionary units of three-dimensional structure. Najeeb Halabi, Olivier Rivoire, Stanislas Leibler, Rama Ranganathan. Cell vol. 138 (4) pp. 774-86 (August 21, 2009)

Dan Le

Inhibitors selective for mycobacterial versus human proteasomes Gang Lin et al Nature, Vol 461, 1 October 2009: pg 621-27

Henry Lin

I plan on doing my journal club (Nov 10th) talk on a paper titled: Comprehensive Mapping of Long-Range Interactions Reveals Folding Principles of the Human Genome Erez Lieberman-Aiden, et al. Science 326: 5950. 289-293. Oct 9, 2009

Andrew Wiser

HDAC2 negatively regulates memory formation and synaptic plasticity" from Nature; vol 459; May 7, 2009

Emmanuel Yera

RNAi in Budding Yeast Ines A. Drinnenberg 1, David E. Weinberg 2, Kathleen T. Xie 2, Jeffrey P. Mower 3, Kenneth H. Wolfe 4, Gerald R. Fink 5, David P. Bartel 2*

Crystal Nyitray

A biological quarter-wave retarder with excellent achromacity in the visible wavelength region. Nature Photonics 3, 641 - 644 (2009) Published online: 25 October 2009 | doi:10.1038/nphoton.2009.189 N. W. Roberts1,2, T.-H. Chiou3, N. J. Marshall3 & T. W. Cronin4

Monica Tremont

Electron Relay in Proteins

Tryptophan-Accelerated Electron Flow Through Proteins. Shih C, Museth AK, Abrahamsson M, Blanco-Rodriguez AM, Di Bilio AJ, Sudhamsu J, Crane BR, Ronayne KL, Towrie M, Vlcek A, Richards JH, Winkler JR, Gray HB. Science 2008 Jun 27 320(5884):1760-2

Michael Lopez

S-nitrosylation of the histone deacetylase 2 induces chromatin remodelling in neurons

Nott, Alexi et al. S-nitrosylation of the histone deacetylase 2 induces chromatin remodelling in neurons. Nature. Advanced online publication, (2008).

Noah Ollikainen

In vivo reprogramming of adult pancreatic exocrine cells to beta-cells

Zhou Q, Brown J, Kanarek A, Rajagopal J, Melton DA. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature advance online publication 27 August 2008.

Gabe Rocklin

Crowded, cell-like environment induces shape changes in aspherical protein

Crowded, cell-like environment induces shape changes in aspherical protein. Dirar Homouz, Michael Perham, Antonios Samiotakis, Margaret S. Cheung, and Pernilla Wittung-Stafshede, PNAS August 19, 2008 vol. 105 no. 33 11754-11759

Nicholas Hertz

A double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms

Michael R. Sawaya, Wof M. Wojtowicz, Ingemar Andre, Bin Qian, Wei Wu, David Baker, David Eisenberg, S. Lawrence Zipursky (2008). A double S Shape Provides the Structural Basis for the Extraordinary Binding Specificity of Dscam Isoforms. Cell 134, 1007-1018

Adam Marko

It's all in your head: The Drosophila pheromone cVA activates a sexually dimorphic neural circuit

Sandeep Robert Datta, Maria Luisa Vasconcelos, Vanessa Ruta, Sean Luo, Allan Wong, Ebru Demir, Jorge Flores, Karen Balonze, Barry J. Dickson & Richard Axel. The Drosophila pheromone cVA activates a sexually dimorphic neural circuit. Nature 452, 473-477 (27 March 2008) doi:10.1038/nature06808.

http://www.nature.com/nature/journal/v452/n7186/full/nature06808.html

Cheryl Tajon

The effect of particle design on cellular internalization pathways

Stephanie E. A. Gratton, Patricia A. Ropp, Patrick D. Pohlhaus, J. Christopher Luft, Victoria J. Madden, Mary E. Napier, and Joseph M. DeSimone. The effect of particle design on cellular internalization pathways. PNAS August 29, 2008
vol. 105
no. 33
11613–11618.

Jennifer Hsiao

Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions

"Domain organization of human chromosomes revealed by mapping of nuclear lamina interactions." Guelen L, Pagie L, Brasset E, Meuleman W, Faza MB, Talhout W, Eussen BH, de Klein A, Wessels L, de Laat W, van Steensel B. Nature. 2008 Jun 12;453(7197):948-51. Epub 2008 May 7.

David Burkhardt

The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions

S. Jhunjhunwala, M. van Zelm, M. Peak, S. Cutchin, R. Riblet, J. van Dongen, F. Grosveld, T. Knoch, C. Mur. The 3D Structure of the Immunoglobulin Heavy-Chain Locus: Implications for Long-Range Genomic Interactions. Cell, Volume 133, Issue 2, Pages 265-279.

Rebecca Maglathlin

"An Alternative Menaqinone Biosynthetic Pathway Operating in Microorganisms"

"An Alternative Menaqinone Biosynthetic Pathway Operating in Microorganisms" Hiratsuka, et. al., Science, 321, 1670 (2008):DOI: 10.1126/science.1160446

Bethany Simmons

Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos

Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos. Desprat N, Supatto W, Pouille PA, Beaurepaire E, Farge E Dev Cell 2008 Sep 15(3):470-7

Jaline Gerardin

A mechanism for asymmetric segregation of age during yeast budding

Shcheprova Z, Baldi S, Frei SB, Gonnet G, Barral Y. A mechanism for asymmetric segregation of age during yeast budding. Nature. 2008 Aug 7;454(7205):728-34.

Brandon Butler

Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation

EM Duncan, TL Muratore-Schroeder, RG Cook, BA Garcia, J Shabanowitz, DF Hunt, and CD Allis. Cathepsin L Proteolytically Processes Histone H3 During Mouse Embryonic Stem Cell Differentiation. Cell, Volume 135, Issue 2, 284-294, 17 October 2008. doi:10.1016/j.cell.2008.09.055

Elaine Kirschke

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations. Li Fan, Jill O. Fuss, Quen J. Cheng, Andrew S. Arvai, Michal Hammel, Victoria A. Roberts, Priscilla K. Cooper and John A. Taine. Cell, Vol 133, Issue 5, 30 May 2008

Hannes Braberg

Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNA

"Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs". Kouji Hirota, Tomoichiro Miyoshi, Kazuto Kugou, Charles S. Hoffman, Takehiko Shibata & Kunihiro Ohta. Nature, Vol 456, 6 November 2008, doi:10.1038/nature07348.

Robin Aglietti

The Acidic Repetitive Domain of the Magnetospirillum gryphiswaldense MamJ Protein Displays Hypervariability but Is Not Required for Magnetosome Chain Assembly

The Acidic Repetitive Domain of the Magnetospirillum gryphiswaldense MamJ Protein Displays Hypervariability but Is Not Required for Magnetosome Chain Assembly. André Scheffel and Dirk Schüler. Journal of Bacteriology, September 2007, p. 6437-6446, Vol. 189, No. 17. doi:10.1128/JB.00421-07

Rand Miller

CASK Functions as a Mg2+-independent Neurexin Kinase

CASK Functions as a Mg2+-independent Neurexin Kinase. Mukherjee, M. et al. Cell, Vol. 133, No. 2, April 18, 2008, p. 328-339

Heather Newman

Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy

Christian W. Freudiger, Wei Min, Brian G. Saar, Sijia Lu, Gary R. Holtom, Chengwei He, Jason C. Tsai, Jing X. Kang, and X. Sunney Xie. Label-Free Biomedical Imaging with High Sensitivity by Stimulated Raman Scattering Microscopy. Science 322 (5909), 1857. (19 December 2008) [DOI:10.1126/science.1165758]

Charlie Kehoe

Structure and function of an RNase H domain at the heart of the spliceosome

Vladimir Pena, Alexey Rozov, Patrizia Fabrizio, Reinhard Lührmann, and Markus C Wahl. Structure and function of an RNase H domain at the heart of the spliceosome. The EMBO Journal (2008) 27, 2929–2940, doi:10.1038/emboj.2008.209 Published online 9 October 2008

http://dx.doi.org/10.1038/emboj.2008.209

George Peterson

Tomas-Loba A, Flores I, Fernandez-Marcos PJ, Cayuela ML, Maraver A, Tejera A, Borras C, Matheu A, Klatt P, Flores JM, Vina J, Serrano M, Blasco MA. Telomerase Reverse Transcriptase Delays Aging in Cancer-Resistant Mice. Cell 135 (2008), 609-622.

Xiuming Wong

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry

Structural and Mechanistic Insights into STIM1-Mediated Initiation of Store-Operated Calcium Entry. P Li, MJ Plevin, M Ikura. Cell, Volume 135, Issue 1, 110-122, 3 October 2008

Peter Skewes-Cox

Antigenic variation in Giardia lamblia is regulated by RNA interference. Nature. 2008 Dec 11;456(7223):750-4

Carrie Shiau

DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45. Rai, K. et al. Cell, Vol 135, No. 7, December 26, 2008, p. 1201-1212.

Joe Kliegman

Sun et al. The structure of the phage T4 DNA packaging motor suggests a mechanism dependent on electrostatic forces. Cell (2008) vol. 135 (7) pp. 1251-62

Chris Wen

Ashok Prasada,Julie Zikhermanb, Jayajit Dasa, Jeroen P. Roosec, Arthur Weissbd1 and Arup K. Chakrabortyaef1. Origin of the sharp boundary that discriminates positive and negative selection of thymocytes. PNAS January 13, 2009 vol. 106 no. 2 528-533

Brittany Belin

Scott Smukalla, Marina Caldara, Nathalie Pochet, Anne Beauvais, Stephanie Guadagnini, Chen Yan, Marcelo D. Vinces, An Jansen, Marie Christine Prevost, Jean-Paul Latge, Gerald R. Fink, Kevin R. Foster, and Kevin J. Verstrepen. (2008) FLO1 Is a Variable Green Beard Gene that Drives Biofilm-like Cooperation in Budding Yeast. Cell 135(4), 726-737.

Jennifer Liu

A tunable synthetic mammalian oscillator. Nature 457, 309-312 (15 January 2009)

David Booth

Byres E, et al. (4 Dec 2008) "Incorporation of a non-human glycan mediates human susceptibility to a bacterial toxin." Nature 456: 648-52.

Jonathan Choy

AMPK and PPARδ Agonists Are Exercise Mimetics.

Narkar, V. A., et al (2008). AMPK and PPARδ Agonists Are Exercise Mimetics. Cell 134, 405-415. doi:10.1016/j.cell.2008.06.051

Daniel Le

Yamagata K, Daitoku H, Takahashi Y, Namiki K, Hisatake K, Kako K, Mukai H, Kasuya Y, Fukamizu A. Arginine methylation of FOXO transcription factors inhibits their phosphorylation by Akt. Mol Cell. 2008 Oct 24;32(2):221-31.

Chris Fuller

Genotype, haplotype and copy-number variation in worldwide human populations. Jakobsson, M. et al. Nature vol 451, 908-1002. 2008

Megan Riel-Mehan

Science 28 November 2008: Vol. 322. no. 5906, pp. 1387 - 1392. An Epigenetic Role for Maternally Inherited piRNAs in Transposon Silencing. Julius Brennecke, Colin D. Malone, Alexei A. Aravin, Ravi Sachidanandam, Alexander Stark, Gregory J. Hannon.

Geoffrey Rollins

Intersubunit coordination in a homomeric ring ATPase. Moffitt et al. Nature 457, 446-450 (2009).

Genevieve Erwin

ChIP-seq accurately predicts tissue-specific activity of enhancers. Axel Visel, Matthew J. Blow, Zirong Li, Tao Zhang, Jennifer A. Akiyama, Amy Holt, Ingrid Plajzer-Frick, Malak Shoukry, Crystal Wright, Feng Chen, Veena Afzal, Bing Ren, Edward M. Rubin & Len A. Pennacchio. Nature Vol 457| 12 February 2009| doi:10.1038/nature07730

Charles Morgan

Quantitive exploration of the catalytic landscape separating divergent plant sesquiterpene synthases". Nature Chemical Biology. October(2008) Vol. 4 Number 10. pg. 617-623. O'Maille et. al.

Russell Spitzer

A stress-responsive RNA switch regulates VEGFA expression. Partho Sarothi Ray, Jie Jia, Peng Yao, Mithu Majumder, Maria Hatzoglou & Paul L. Fox Nature. 457. 915-919. 2009

Edwin Rodriguez

Self-Sustained Replication of an RNA Enzyme. Science 323, 1229 (2009) Tracey A. Lincoln et al.

Emmanuel Yera

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Sonia A Melo, Santiago Ropero, Catia Moutinho, Lauri A Aaltonen, Hiroyuki Yamamoto, George A Calin, Simona Rossi, Agustin F Fernandez, Fatima Carneiro, Carla Oliveira, Bibiana Ferreira, Chang-Gong Liu, Alberto Villanueva, Gabriel Capella, Simo Schwartz Jr, Ramin Shiekhattar & Manel Esteller. Nature Genetics 41, 365 - 370 (2009) Published online: 15 February 2009 | doi:10.1038/ng.317

Dan Lu

Julien F Ayroles et al. Systems genetics of complex traits in Drosophila melanogaster. Nat Genet (2009) vol. 41 (3) pp. 299

Roxana Ordonez

Cohen et al. Dynamic proteomics of individual cancer cells in response to a drug. Science (2008) vol. 322 (5907) pp. 1511-6

Andrew Wiser

"Monomeric fluorescent timers that change color from blue to red report on cellular trafficking". Subach et al. Nature Chemical Biology (2009) Volume 5 Number 2 February 2009 118-126

Henry Lin

Variants of the Antibody Herceptin That Interact with HER2 and VEGF at the Antigen Binding Site. Jenny Bostrom, Shang-Fan Yu, David Kan, Brent A. Appleton, Chingwei V. Lee, Karen Billeci, Wenyan Man, Franklin Peale, Sarajane Ross, Christian Wiesmann, Germaine Fuh. Science 323, 1610 (2009)

Samuel Myers

Histone h3 lysine 56 acetylation is linked to the core transcriptional network in human embryonic stem cells. Xie W, Song C, Young NL, Sperling AS, Xu F, Sridharan R, Conway AE, Garcia BA, Plath K, Clark AT, Grunstein M. Mol Cell. 2009 Feb 27;33(4):417-27.

Anthony Shiver

Nature Structural & Molecular Biology. Helix Sliding in the stalk coiled coil of dynein couples ATPase and microtubule binding Takashide Kon et al. Vol 16 numb 3 march 2009

Joanna Lipinski

Non-genetic origins of cell-to-cell variability in TRAIL-induced apoptosis. Sabrina L. Spencer, Suzanne Gaudet, John G. Albeck, John M. Burke & Peter K. Sorger. (doi:10.1038/nature08012)

Idelisse Ortiz Torres

Selective Erasure of a Fear Memory Jin-Hee Han, Steven A. Kushner, Adelaide P. Yiu, Hwa-Lin (Liz) Hsiang, Thorsten Buch, Ari Waisman, Bruno Bontempi, Rachael L. Neve, Paul W. Frankland, and Sheena A. Josselyn (13 March 2009) Science 323 (5920), 1492. [DOI: 10.1126/science.1164139]

Ryan Gile

Stretching Single Talin Rod Molecules Activates Vinculin Binding. Armando del Rio. Science (January 2009).

Linh Ho

Linh Ho: AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity Nature 458, 1056-1060, 2009.

James Kraemer

Ligand-Dependent Equilibrium Fluctuations of Single Calmodulin Molecules. Jan Philipp Junker, Fabian Ziegler, and Matthias Rief. Science 30 January 2009: 633-637.

Rocco Varela

Rocco Varela: An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer Nature. 2009 Apr 9;458(7239):732-6

Maya Chandru

Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion.

Wolf et al, Nat Cell Biol 2007 Aug 9

Brianna Burden

Aptamer Displacement Identifies Alternative Small-Molecule Target Sites that Escape Viral Resistance

amazaki et al, Cell: Chemistry and Biology 14, 804-812, 2007.

Jeremy Phillips

Two distinct modes of guidance signalling during collective migration of border cells.

Bianco A, Poukkula M, Cliffe A, Mathieu J, Luque CM, Fulga TA, Rorth P. Nature. 2007 Jul 19;448(7151):362-5.

Reid Williams

Selection and evolution of enzymes from a partially randomized non-catalytic scaffold

Seelig B, Szostak JW. Nature. 2007 Aug 16;448(7155):828-31.

Daniel Gray

Crystal Structure of an Ancient Protein: Evolution by Conformational Epistasis.

Ortlund, Bridgham, Redinbo, Thornton. Science. 2007 Sep 14;317(5844):1544-8. Epub 2007 Aug 16.

http://www.nature.com/nsmb/journal/v14/n9/abs/nsmb1280.html

Rebeca Choy

In vivo dynamics of RNA polymerase II transcription

Xavier Darzacq, Yaron Shav-Tal, Valeria de Turris, Yehuda Brody, Shailesh M Shenoy, Robert D Phair & Robert H Singer. Nature Structural & Molecular Biology - 14, 796 - 806 (2007).

Charles Biddle-Snead

Array Tomography: A New Tool for Imaging the Molecular Architecture and Ultrastructure of Neural Circuits

Kristina D. Micheva and Stephen J Smith. Neuron 55, 25–36, July 5, 2007 ª2007 Elsevier Inc. 25

Iana Serafimova

Splicing factor SF3b as a target of the antitumor natural product pladienolide

Yoshihiko Kotake1, Koji Sagane1, Takashi Owa, Yuko Mimori-Kiyosue, Hajime Shimizu, Mai Uesugi, Yasushi Ishihama, Masao Iwata & Yoshiharu Mizui. Nature Chemical Biology, Vol 3, Number 9, September 2007, p570 - 575.

Daniele Canzio

A motor that makes his own track: helicase unwinding of DNA: Single-Molecule Studies Reveal Dynamics of DNA unwinding by the Ring-Shaped T7 Helicase

Cell 129, 1299-1309, June 29, 2007

David Stanley

Dynamic Scaffolding of a G Protein-Coupled Signaling System

Prashant Mishra, Michael Socolich, Mark A. Wall, Jennifer Graves, ZiFen Wang, and Rama Ranganathan. Cell, Vol 131, 80-92, 05 October 2007

Kris Kuchenbecker

Energetics and dynamics of SNAREpin folding across lipid bilayers.

Nature Structural and Molecular biology. October 2007.

Laura Lavery

High-afinity single-domain binding proteins with a binary-code interface.

Akiko Koidea, Ryan N. Gilbreth, Kaori Esaki, Valentina Tershko, Shohei Koide. PNAS, Vol 104, No. 16. April 17, 2007.

http://www.pnas.org/cgi/content/full/104/16/6632

Sheel Dandekar

Ordered phosphorylation governs oscillation of a three-protein circadian clock

Rust MJ, Markson JS, Lane WS, Fisher DS, O'Shea EK. Science. 2007 Nov 2;318(5851):809-12. Epub 2007 Oct 4.

Jonathan Choy

Design of Cyclic Peptides That Bind Protein Surfaces with Antibody-Like Affinity

Steven W. Millward, Stephen Fiacco, Ryan J. Austin, and Richard W. Roberts (2007) ACS Chem. Biol. 2, 625-634.

Sai Duriseti

A Simple DNA-Based Translation System

Alejandra V. Garibotti, Shiping Liao, and Nadrian C. Seeman. Nano Letters 2007 Vol. 7, No. 2. 480-483.

Ryan Ritterson

Retroposons: DNA parasites or facilitators? A CORE-SINE retroposon as a highly conserved neuronal enhancer.

Ancient Exaptation of a CORE-SINE Retroposon into a Highly Conserved Mammalian Neuronal Enhancer of the Proopiomelanocortin Gene. Santangelo AM, de Souza FSJ, Franchini LF, Bumaschny VF, Low MJ, et al. PLoS Genetics Vol. 3, No. 10, e166doi:10.1371/journal.pgen.0030166

http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0030166

Charles Kehoe

Functional specificity among ribosomal proteins regulates gene expression.

Komili S, Farny NG, Roth FP, Silver PA.Cell. 2007 Nov 2;131(3):450-1.

David Booth

Solvent Tuning of Electrochemical Potentials in the Active Sites of HiPIP Versus Ferredoxin

Solvent Tuning of Electrochemical Potentials in the Active Sites of HiPIP Versus Ferredoxin Abhishek Dey, Francis E. Jenney, Jr., Michael W. W. Adams, Elena Babini, Yasuhiro Takahashi, Keiichi Fukuyama, Keith O. Hodgson, Britt Hedman, Edward I. Solomon, Science, 318, 1464-8, 2007

Joseph Kliegman

Minor Details of Transcription Factor Specificity

Rohit Joshi, Jonathan M. Passner, Remo Rohs, Rinku Jain, Alona Sosinsky, Michael A. Crickmore, Vinitha Jacob, Aneel K. Aggarwal, Barry Honig and Richard S. Mann. Functional Specificity of a Hox Protein Mediated by the Recognition of Minor Groove Structure, CellVolume 131, Issue 3, , 2 November 2007, Pages 530-543.

Michael Lopez

A GluR1-cGKII Interaction Regulates AMPA Receptor Trafficking

Yafell Serulle, Shuang Zhang, Ipe Ninan, Daniela Puzzo, Maria McCarthy, Latika Khatri, Ottavio Arancio, and Edward B. Ziff Neuron 56, 670�¢ï¿½ï¿½688, November 21, 2007

Noah Ollikainen

Somewhere over the brainbow

Jean Livet, Tamily A. Weissman, Hyuno Kang, Ryan W. Draft, Ju Lu, Robyn A. Bennis, Joshua R. Sanes & Jeff W. Lichtman. Transgenic strategies for combinatorial expression of fluorescent proteins in the nervous system. Nature. 450, 56-62 (2007).

http://www.nature.com/nature/journal/v450/n7166/abs/nature06293.html

George Peterson

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Belenky P, Racette FG, Bogan KL, McClure JM, Smith JS, Brenner C. Cell 129: 473-84 (2007)

http://www.cell.com/content/article/abstract?uid=PIIS009286740700390X

Rebecca Maglathlin

Structural Rearrangements of NR1/NR2A NMDA Receptors during Allosteric Inhibition

Marc Gielen, Anne Le Goff, David Stroebel, Jon W. Johnson, Jacques Neyton, and Pierre Paoletti. Neuron 57, 80�93, January 10, 2008

Heather Newman

Multicolor Super-Resolution Imagining with Photo-switchable Fluorescent Probes

Multicolor Super-Resolution Imagining with Photo-switchable Fluorescent Probes Mark Bates et al., Science 317, 1749 (2007).

Peter Skewes-Cox

Will newly identified host factors exploited by HIV make good drug targets?

"Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen," Abraham L. Brass, Derek M. Dykxhoorn, Yair Benita, Nan Yan, Alan Engelman, Ramnik J. Xavier, Judy Lieberman, Stephen J. Elledge. Science, 2008 Jan 10

http://www.sciencemag.org/cgi/content/abstract/1152725v

David Burkhardt

Switching from repression to activation: microRNAs can up-regulate translation.

Vasudevan S, Tong Y, Steitz JA, " Switching from repression to activation: microRNAs can up-regulate translation.", Science 2007 Dec 21

Hannes Braberg

High-content single-cell drug screening with phosphospecific flow cytometry

Peter O Krutzik, Janelle M Crane, Matthew R Clutter and Garry P Nolan. Nature Chemical Biology 4, 132-142 (2007) doi:10.1038/nchembio.2007.59

Rand Miller

Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target

Peer, D., Park, E. J., Morishita, Y., Carman, C. V., Shimaoka, M, "Systemic Leukocyte-Directed siRNA Delivery Revealing Cyclin D1 as an Anti-Inflammatory Target," /Science/, 319, 627-630, (2008). DOI: 10.1126/science.1149859

Nicholas Hertz

A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol

Blankman, J.L., Simon, G.M., Cravatt, B.F. (2007). A Comprehensive Profile of Brain Enzymes that Hydrolyze the Endocannabinoid 2-Arachidonoylglycerol. Chem. Biol. 14, 1347-1356

Elaine Kirschke

Activation of the Chaperone Hsp26 Is Controlled by the Rearrangement of Its Thermosensor Domain

T. Franzmann, P. Menhorn, S. Walter, and J. Buchner. (2008) Activation of the Chaperone Hsp26 Is Controlled by the Rearrangement of Its Thermosensor Domain. Molecular Cell, Vol 29, 207-216, 01

Bethany Simmons

Global analysis of mRNA localization reveals a prominent role in organizing cellular architecture and function.

Lecuyer E, Yoshida H, ..., Tomancak P, Krause HM Cell 2007 Oct 5 131(1):174-87

Kiyoshi Egami

Glycan topology determines human adaptation of avian H5N1 virus hemagglutinin.

Chandrasekaran A, Srinivasan A, Raman R, Viswanathan K, Raguram S, Tumpey TM, Sasisekharan V, Sasisekharan R. Nat Biotechnol. 2008 Jan;26(1):107-13. Epub 2008 Jan 6.

Brandon Butler

A beta-arrestin 2 Signalling Complex Mediates Lithium Action on Behavior

Jean-Martin Beaulieu et al. Cell, 132, 125-136, Jan 11, 2008.

Jaline Gerardin

Direct observation of hierarchical folding in single riboswitch aptamers

Greenleaf WJ, Frieda KL, Foster DAN, Woodside MT, Block SM. Direct observation of hierarchical folding in single riboswitch aptamers. Science. 2008 Feb 1;319(5863):630-3.

Carrie Shiau

Transcriptional repression mediated by repositioning of genes to the nuclear lamina

Reddy, K. L. et al. Transcriptional repression mediated by repositioning of genes to the nuclear lamina. Nature 452, 243 – 247 (2008).

Adam Marko

Computational Enzyme Design

Lin Jiang, Eric A. Althoff, Fernando R. Clemente, Lindsey Doyle, Daniela Röthlisberger, Alexandre Zanghellini, Jasmine L. Gallaher, Jamie L. Betker, Fujie Tanaka, Carlos F. Barbas, III, Donald Hilvert, Kendall N. Houk, Barry L. Stoddard, David Baker. De Novo Computational Design of Retro-Aldol Enzymes. Science 7 March 2008: Vol. 319. no. 5868, pp. 1387 - 139. DOI: 10.1126/science.1152692

Jennifer Hsiao

Hydrodynamic Flow-Mediated Protein Sorting on the Cell Surface of Trypanosomes

Markus Engstler, Thomas Pfohl, Stephan Herminghaus, Michael Boshart, Geert Wiegertjes, Niko Heddergott, and Peter Overath. Cell 131, 505–515, November 2, 2007

Jennifer Liu

Preserving cell shape under environmental stress

Boaz Cook, Robert W Hardy, William B McConnaughey, Charles S Zuker. Nature 452, 361-364 (20 March 2008), doi:10.1038/nature06603

Gabriel Rocklin

Integrating high-content screening and ligand-target prediction to identify mechanism of action

Young, DW et al. Integrating high-content screening and ligand-target prediction to identify mechanism of action. Nature Chemical Biology 4:1 Jan 2008

Cheryl Tajon

Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy

Andre´ M. Gobin, Min Ho Lee, Naomi J. Halas, William D. James, Rebekah A. Drezek, and Jennifer L. West. Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer Therapy. Nano Letters, 2007, vol. 7, no. 7, 1929-34.

Brittany Belin

Structural basis of membrane invagination by F-BAR domains

Frost A, Perera R, Roux A, Spasov K, Destaing O, Egelman EH, De Camilli P, Unger VM. (2008) Structural basis of membrane invagination by F-BAR domains. Cell 132(5):807-17.

Xiu Ming Wong

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